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According to the American Society of Plastic Surgeons, over a million and a half filler injections were performed in 2010.  Did you know that most facial fillers, such as Radiesse, Juvederm, Restylane and others that are FDA approved are approved for only the smile lines (Naso-labial folds)?  Some of the common off-label areas to inject with these fillers are the marionette lines, lips and vertical lipstick lines, corners of the mouth, under eye area and other depressed areas of the face and hands.  Restylane, a hyaluronic acid filler, created by Medicis, is the first filler to receive FDA approval for lips.  Check out this article, http://www.restylaneusa.com/restylane_for_lip_enhancement/default.aspx